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Fig. S10. Geminin repression of mesodermal gene expression is not sensitive to inhibition of histone deacetylase activity. Embryos were injected with Gemininδcoil mRNA (300 pg; one cell out of two cells) and half of the embryos were treated from the two-cell stage (immediately after injection) with 100 nM TSA, followed by in situ hybridization at stage 11. (A,B) Geminin repressed Brachyury expression in untreated and TSA (100 nM)-treated embryos. (C) Fraction of embryos showing the phenotypes in A and B is indicated (additive quantitation from two experiments). (D) Gemininδcoil-injected embryos were used to prepare animal cap explants and were treated with Activin as before, plus and minus TSA co-treatment. Geminin repressed Activin-induced Brachyury expression with similar efficiency in the presence and absence of TSA treatment.

Image published in: Lim JW et al. (2011)

Copyright © 2011. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.

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