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XB-IMG-49652

Xenbase Image ID: 49652


Fig. 3. The effect of Coco MO on asymmetrically expressed genes. Stage 256 embryos were stained by in situ hybridization for Pitx2c (A), Xnr1 (D), and Xlefty-a (G). Left and right sides of the same embryos are shown. Panels G are dorsal views of cleared embryos, showing midline expression of Xlefty-a. Embryos injected in the right dorsal blastomere with 3 ng Coco MO have mostly bilateral expression of Pitx2c (B), Xnr1 (E), and Xlefty-a (H). Coinjection of Mut Coco RNA (10 pg) restores left-side expression in Coco MO-injected embryos (Pitx2c C, Xnr1 F, Xlefty-a I). Panels A, D, G are controls. Embryos in panels A were coinjected with 1 ng LacZ RNA and stained with Red Gal, to show that the right side was correctly targeted.

Image published in: Vonica A and Brivanlou AH (2007)

Copyright © 2007. Image reproduced on Xenbase with permission of the Publisher, Elsevier B. V.

GeneCloneSynonymsSpeciesStage(s)Tissue
pitx2.L pitx2-A, xPtx2, xpitx2, pitx2c, pitx2-a, pitx2-bX.laevisSometime during NF stage 25 to NF stage 26lateral plate mesoderm
left
nodal1.L nr1, Xnr-1, Xnr1, nodal-related 1, nr1-a, spaw, nodalX.laevisSometime during NF stage 25 to NF stage 26mesoderm
notochord
lateral plate mesoderm
left
lefty.L leftb, leftyb, lefty-1, antivin, atv, Xlefty, XATV, lefty1, lefty-a, lefty-bX.laevisSometime during NF stage 25 to NF stage 26floor plate
hypochord
left

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