Xenbase Image ID: 73888

Fig.4. Ectopic Shh does not affect notochord formation and Notch signaling acts after specification to repress the notochord fate. Shh mRNA overexpression does not repress notochord specification at stage 10, assayed by chd (B) and Xbra (E), or notochord formation during gastrulation (Xbra, H). Activated Notch signaling does not affect notochord specification (C, F), but potently represses subsequent notochord formation (I). Pink is lacZ staining of co-injected lineage tracer. Image published in: Peyrot SM et al. (2011) Copyright © 2011. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue chrd.S chd, chordin, chrd.1, LOC108716939, X-chordin X. laevis Throughout NF stage 10 dorsal marginal zone tbxt.L bra, brachyury, ntl, t, t-a, t-b, X-bra, Xbra, Xbrachyury X. laevis Throughout NF stage 10 marginal zone mesoderm tbxt.L bra, brachyury, ntl, t, t-a, t-b, X-bra, Xbra, Xbrachyury X. laevis Throughout NF stage 13 notochord axial mesoderm circumblastoporal collar Image source: Published Experiment + Assay Source Phenotypes and Disease Xla Wt + canotch1 + NF13 (immunohistochemistry) fig.4.i Anatomical Phenotype abnormal development of notochord Xla Wt + canotch1 + NF13 (in situ hybridization) fig.4.i Expression Phenotype decreased amount tbxt.L expression in notochord Larger Image Printer Friendly View

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