Xenbase Image ID: 73902

Fig.1. Xenopus crescent is expressed dorsally and repressed by BMP signaling. (A) D–V Patterning is regulated by proteins secreted by the dorsal and ventral signaling centers. For the proteins listed, proteins of similar function are secreted by the two sides, but under opposite transcriptional control. (B) sFRPs of Xenopus (x), human (h), zebrafish (z) and chicken (ch) origin were compared using Molecular Evolutionary Genetics Analysis (MEGA) software (Tamura et al., 2007). Crescent and Sizzled are philogenetically related, and distant from the other sFRPs. (C–E) Crescent expression is under negative transcriptional control by BMP4 signaling. Microinjection of Chordin (Chd) protein increases crescent transcripts, while microinjection of BMP4 protein decreases crescent expression in stage 12 gastrulae. (F-H) sizzled expression is inhibited by injection of crescent mRNA and markedly expanded upon depletion of Crescent (Cres MO); an uninjected sibling at stage 11 is shown for comparison. Image published in: Ploper D et al. (2011) Copyright © 2011. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View

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