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Fig. 5. Development of glucagon and somatostatin expressing cells in Ptf1a and Ptf1a-VP16-injected embryos. (A) In situ hybridization for glucagon expression in control, Ptf1a and Ptf1a-VP16-injected embryos at stage 45. (B) Stomach and duodenal expression of glucagon is absent, while pancreatic glucagon expression appears slightly reduced in Ptf1a-injected ectopic pancreas phenotype. (C) No glucagon expression is detected in Ptf1a-VP16-injected embryos. (D) Somatostatin expression. (E) Overall somatostatin expression is reduced in Ptf1a-injected embryos. Pancreatic expression appears normal, while stomach and duodenal expression is completely absent. (F) Somatostatin expression is completely absent in Ptf1a-VP16-injected embryos. Image published in: Jarikji ZH et al. (2007) Copyright © 2007. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View

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