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Figure 5. Loss of insulin receptor substrate IRS-1 function in neural tissue results in a severe eye phenotype. A: Upper panel: Representative embryos displaying the observed eye phenotypes upon IRS-1 morpholino oligonucleotide (MO) injection (arrows). Lower panel: Cross-sections through the affected eyes. B: Quantitative representation of the dose-dependent effect of IRS-1 MO is given. C: Coinjection of the δ5′ untranslated region (UTR) IRS-1 construct significantly rescued the IRS-1 MO-induced phenotype. *P < 0.05, n, number of independent experiments; N, total number of embryos examined.Download figure to PowerPoint Image published in: Bugner V et al. (2011) Copyright © 2011. Image reproduced with permission of the Publisher, John Wiley & Sons. Larger Image Printer Friendly View

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