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XB-IMG-74770

Xenbase Image ID: 74770

Figure 6. Marker gene analyses of Insulin receptor substrate IRS-1-depleted embryos. A: IRS-1 knock down in neural tissue reduces the expression of the eye marker genes Rx1 and Pax6, but not the pan-neural marker gene Sox3 at stage 13. B: At stage 23, expression of Rx1, Pax6, and Otx2 in the eye is affected. In contrast, expression of Emx1, Krox20, and En2 in the brain is not affected. C: Coinjection of 0.5 ng of δ5′ untranslated region (UTR) IRS-1 RNA significantly reverted the IRS-1 morpholino oligonucleotide (MO) (20 ng) -induced reduction of Rx1 expression at stage 13. D,E: Quantitative representations are given. *P < 0.05, **P < 0.005, n, number of independent experiments; N, total number of embryos examined.Download figure to PowerPoint

Image published in: Bugner V et al. (2011)

Copyright © 2011. Image reproduced with permission of the Publisher, John Wiley & Sons.

GeneSynonymsSpeciesStage(s)Tissue
rax.Srx1, Xrx1, Xrax, Rx2A, rx, rx1a, rax-a, rax1, Xrx1A, rax-b, rx-1X.laevisThroughout NF stage 13optic field
pre-chordal neural plate
rax.Srx1, Xrx1, Xrax, Rx2A, rx, rx1a, rax-a, rax1, Xrx1A, rax-b, rx-1X.laevisThroughout NF stage 23eye
retina
emx1l.SXEmx1X.laevisThroughout NF stage 23forebrain
telencephalon
pax6.LXLPAX6, xpax6, pax-6, an2, mgda, wagr, pax6-a, pax6-bX.laevisThroughout NF stage 13lens placode
spinal cord
pre-chordal neural plate
optic field
pax6.LXLPAX6, xpax6, pax-6, an2, mgda, wagr, pax6-a, pax6-bX.laevisThroughout NF stage 23lens placode
eye
forebrain
brain
retina
egr2.LXKr20, EGR-2, Krox-20, XKrox-20, krox20X.laevisThroughout NF stage 23rhombomere
rhombomere R3
rhombomere R5
sox3.SxSox3, Sry, Xtsox3, Xlsox3X.laevisThroughout NF stage 13lens placode
neural plate
pre-chordal neural plate
chordal neural plate
otx2.SXotx2, otx-2, Xotx-2, otxA, otx2-a, otx2-bX.laevisThroughout NF stage 23eye
brain
forebrain
midbrain

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