Xenbase Image ID: 74863

Fig. 7. Activation of Wnt/β-catenin signals inhibits neuronal precursor formation. (A) Schematic showing the XLef1 and XTcf3 constructs utilized in these experiments. (B) Upregulation of canonical Wnt signals via expression of δβ-catenin (i, iv, vii) or constitutively activating forms of XLef1 or XTcf3 (β-cateninδXLef1, ii, v, viii; β-cateninδXTcf3, iii, vi, ix) expands expression of the neural crest marker Slug (iii) and inhibits expression of the pan-neural markers Sox3 (ivi) and Nrp1 (viiix). The red arrow in panels v, vi, and ix point to cleared patches of staining where the Wnt pathway is ectopically activated. (C) The inhibition of Sox3 by β-cateninδXTcf3 (ii, v) can be rescued by coexpression of δXTcf3 (iii, vi). Image published in: Heeg-Truesdell E and LaBonne C (2006) Copyright © 2006. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue snai2.L slug, snai2-a, snai2-b, Snail2, xSlu, xslug, XSnail2 X. laevis Throughout NF stage 18 neural crest cranial neural crest sox3.S Sry, Xlsox3, xSox3, Xtsox3 X. laevis Throughout NF stage 18 neuroectoderm neural plate pre-chordal neural plate chordal neural plate anterior neural ridge nrp1.L A5 antigen, LOC108718763, neuropilin, neuropilin-1, np-1, npn-1, nrp, nrp-1, pNPG152 X. laevis Throughout NF stage 18 neuroectoderm neural plate sox3.S Sry, Xlsox3, xSox3, Xtsox3 X. laevis Throughout NF stage 16 neuroectoderm neural plate Image source: Published Larger Image Printer Friendly View

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