Xenbase Image ID: 75334

Figure 4. Irx gene expression is confined to distinct segments of Henle’s loop in the adult metanephric kidney. (A–F) Expression of Irx genes in the adult kidney. In situ hybridizations were performed on paraffin sections. Whole sagittal sections (A–C) and magnifications (D–F) are shown to illustrate Irx gene expression in detail. (Co) Cortex; (OS) outer stripe of outer medulla; (IS) inner stripe of the outer medulla; (IM) inner medulla. (A,B,D,E) Irx1 and Irx2 transcripts are detected in S3 and TAL. (C,F) Irx3 transcripts are confined to S3 only. (G) Summary of Irx gene expression in the adult metanephric kidney. The segmental organization of the adult metanephric nephron is shown schematically. The expression domains of each Irx gene are indicated below the scheme. (ATL) Ascending thin limb; (CD) collecting duct; (CDS) collecting duct system; (CNT) connecting tubule; (DCT) distal convoluted tubule; (DTL) descending thin limb; (S1, S2, S3) segments of the proximal tubule; (TAL) thick ascending limb. Image published in: Reggiani L et al. (2007) Copyright © 2007. Image reproduced on with permission of the Publisher, Cold Spring Harbor Laboratory Press. This is an Open Access article. Larger Image Printer Friendly View

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