Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Xenbase Image ID: 75342

Figure 4. Heterochrony and Heterometry in Gene Expression Evolution(A) A sigmoid is defined by b1, t1, h0, and h1 (see text).(B) The ORAI2 gene expression profiles (log10 relative concentrations) in both X. laevis and X. tropicalis is shown fitted by sigmoids.(C) Plots of t1 (time of induction) for pairs of genes with >0.8 goodness of fit in both species. The green line is unity and the red is fitted to the data.(D) Plots of h1 (range of expression). Same format as (C).(E and F) Heterochrony/heterometry phase-plane for families of transcription factors (E) and several signaling pathways (F). The circles and lines indicate the mean and standard deviation of each gene set's heterochronies and heterometries. The transcription factor families are helix-loop-helix (PF00010, 27 genes with sigmoids), Homeobox (IPR001356, 74 genes), Zinc finger (C2H2 type, IPR007087, 24 genes), T-box (IPR001699, 5 genes), Fox head (IPR001766, 16 genes), and HMG (IPR000910, 8 genes). The signaling pathways are Wnt receptor (GO:0016055, 18 genes with sigmoids), transforming growth factor beta receptor (GO:0007179, 13 genes), Hedgehog (GO:0007224, 6 genes), Transmembrane receptor protein tyrosine kinase (GO:0007169, 17 genes), Notch (GO:0007219, 9 genes), Apoptosis (GO:0006917, 40 genes), and G protein-coupled receptor protein (GO:0007186, 73 genes).

Image published in: Yanai I et al. (2011)

Copyright © 2011. Image reproduced on Xenbase with permission of the Publisher, Elsevier B. V.

Larger Image
Printer Friendly View

Return to previous page
Xenbase: The Xenopus laevis and X. tropicalis resource.
Version: 4.9.1
Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556