Xenbase Image ID: 75438

Fig. 1. AGN193109 efficiently depletes retinoid signalling in vivo. (A) The RAR antagonist AGN193109 rescues the RA phenotype. Xenopus laevis embryos incubated in 10-6 M RA show anterior truncations. Embryos incubated in 10-6 M and 10-7 M AGN show a shorter hindbrain area and a large heart oedema with the phenotype being more severe at 10-6 M. When embryos are incubated in equal concentrations (10-6 M) of RA and AGN the resulting phenotype is more like the AGN phenotype. When 10-6 M RA is combined with 10-7 M AGN the phenotype is more like an RA phenotype. NT (control). Image published in: Lloret-Vilaspasa F et al. (2010) Copyright © 2010. Reproduced with permission of the Publisher, University of the Basque Country Press. Larger Image Printer Friendly View

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