Xenbase Image ID: 75478

Fig. 1. Lef1 depletion affects expression of genes in the ventral and dorsal mesoderm. In situ hybridization for X. tropicalis lef1 RNA at stage 10.5 (A) shows high levels of expression in the lateral and ventral marginal zone, low expression in the ectoderm and in the dorsal marginal zone (dorsal side up). Expression of marker genes in gastrula stage embryos, stage 10.5 (B), dorsal side up. Lef1 depletion does not alter the expression of brachyury, wnt8 or myf5. Msr/APJ expression is down- regulated by lef1 depletion whereas nodal related 3 (nr-3) expression is upregulated. Co-injection of human LEF1 RNA rescues the expression of msr/APJ and partially downregulates nr-3 expresssion. Image published in: Roel G et al. (2009) Copyright © 2009. Reproduced with permission of the Publisher, University of the Basque Country Press. Gene Synonyms Species Stage(s) Tissue tbxt bra, brachyury, ntl, t, t-a, t-b, X-bra, Xbra, Xbrachyury X. tropicalis Throughout NF stage 10.5 marginal zone wnt8a wnt-8, wnt8, Xwnt-8, Xwnt8 X. tropicalis Throughout NF stage 10.5 ventral marginal zone ventro-lateral marginal zone myf5 myf-5, Xmyf-5, Xmyf5 X. tropicalis Throughout NF stage 10.5 dorso-lateral marginal zone aplnr agtrl1, angio1, apj, apjr, aplnr-a, aplnr-b, hg11, msr, X-msr, Xangio1, Xmsr X. tropicalis Throughout NF stage 10.5 ventral marginal zone dorso-lateral marginal zone ventro-lateral marginal zone lef1 lef-1, xlef-1, xlef1 X. tropicalis Throughout NF stage 10.5 marginal zone blastopore lip upper blastopore lip lower blastopore lip nodal3.1 nr3, Xnr-3, Xnr3 X. tropicalis Throughout NF stage 10.5 upper blastopore lip dorsal marginal zone Image source: Published Larger Image Printer Friendly View

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