Xenbase Image ID: 75480

Fig. 3. Ectodermal derivatives are affected by lef1 depletion. Transverse section of the eye of a control X. tropicalis stage 38 embryo (A) shows differentiation of retina and lens. Transverse section of the eye of a lef1 depleted embryo (B) shows that the retina and lens have not developed properly and that the lens has not separated from the epidermal ectoderm. Detail of the epidermis showing a ciliated cell (arrow) of a control embryo (C). Lef1 depleted embryos (D) lack ciliated cells in the epidermis. Rescue of ciliated cells (arrow) in the epidermis of embryos injected with lef1 MO together with human LEF1 RNA (E). Expression of the neural crest marker gene tfap2a in a control embryo (F) and reduced expression in a lef1 depleted embryo (G). Image published in: Roel G et al. (2009) Copyright © 2009. Reproduced with permission of the Publisher, University of the Basque Country Press. Gene Synonyms Species Stage(s) Tissue tfap2a ap2, AP2a, AP2alpha, tfap2a-a, tfap2a-b, tfap2alpha, XAP-2, xap2 X. tropicalis Throughout NF stage 22 neural crest central nervous system Image source: Published Larger Image Printer Friendly View

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