Xenbase Image ID: 75825

Fig. 3. Wnt, Fgf and Notch signaling pathways regulate Runx1. Overexpression of Fgf8a by injection of Fgf8a mRNA in one blastomere at the 2-cell stage results in an expansion of the Runx1 expression domain. The expression domain of N-Tub and Ngnr1 is also expanded in these embryos. Knockdown of Fgf8a (Fgf8aMO) causes a severe reduction of all three genes. Similarly, interference with canonical Wnt signaling, by injection of Wnt8MO or β-catMO, reduces Runx1, N-Tub and Ngnr1 expression in all three populations of primary neurons. Expression of an activated form of Notch (Notch-ICD) also represses Runx1 expression. In all panels embryos are viewed from the dorsal side, anterior to top. The injected side is on the right. Image published in: Park BY et al. (2012) Copyright © 2012. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue runx1.L aml, aml-1, aml1, aml1 oncogene, aml1-evi-1, amlcr1, cbfa2, evi-1, LOC108709238, pebp2ab, Runx-1, Xaml, Xaml1 X. laevis Throughout NF stage 19 Rohon-Beard neuron neurog2.L atoh4, neurog2-a, neurog2-b, neurogenin 2, neurogenin-2, neurogenin-related-1, neurogenin2, ngn-2, ngn2, ngnr, ngnr 1a, Ngnr-1, Ngnr1, X-ngnr-1, xngn2, Xngnr-1, XNgnr1 X. laevis Throughout NF stage 19 neural tube tubb2b.S N-Tub, n-tubulin, NBT, neural beta-tubulin, NST, ntubulin, Xn-tubulin X. laevis Throughout NF stage 19 Rohon-Beard neuron Image source: Published Larger Image Printer Friendly View

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