Xenbase Image ID: 75829

Fig. 7. Ngnr1 expression is not sufficient to activate Runx1 expression. (A) Embryos at the 2-cell stage were injected in one blastomere with 0.5 ng of Ngnr1-GR mRNA. Embryos were subsequently incubated with dexamethasone at early (+ Dex 10.5) or late (+ Dex 12.5) gastrula stages, and fixed at stage 15 for detection of Runx1, N-Tub or Pak3 by whole mount in situ hybridization. N-Tub and Pak3 are dramatically upregulated while the Runx1 expression domain is only marginally affected. The injected side is on the right. Dorsal view anterior to top. (B) At the tailbud stage (stage 27) these embryos show ectopic Kv1.1 and Islet1 expression in the ectoderm, independently of any upregulation of Runx1. Lateral views dorsal to top. Control and injected sides of the same embryo are shown for comparison. Image published in: Park BY et al. (2012) Copyright © 2012. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue runx1.L aml, aml-1, aml1, aml1 oncogene, aml1-evi-1, amlcr1, cbfa2, evi-1, LOC108709238, pebp2ab, Runx-1, Xaml, Xaml1 X. laevis Throughout NF stage 15 Rohon-Beard neuron runx1.L aml, aml-1, aml1, aml1 oncogene, aml1-evi-1, amlcr1, cbfa2, evi-1, LOC108709238, pebp2ab, Runx-1, Xaml, Xaml1 X. laevis Throughout NF stage 27 ventral blood island olfactory placode vestibulocochlear ganglion tubb2b.S N-Tub, n-tubulin, NBT, neural beta-tubulin, NST, ntubulin, Xn-tubulin X. laevis Throughout NF stage 15 neural tube Rohon-Beard neuron pak3.L bpak, cdkn1a, mrx30, mrx47, ophn3, pak3beta, XPak3 X. laevis Throughout NF stage 15 neural tube Rohon-Beard neuron isl1.S islet-1, islet1, Xisl-1, Xislet-1 X. laevis Throughout NF stage 27 epithelium Image source: Published Larger Image Printer Friendly View

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