Xenbase Image ID: 75838

Fig. S1. Wnt11 signaling is involved in neural crest formation. Embryos were injected with Wnt11 (1 ng), dnWnt11 (2 ng) mRNAs or Wnt11R MO1 (40 ng) and were analyzed by in situ hybridization at stage 14/15 as described in Fig. 1. Wnt11 RNA expands the neural plate border marked by Hairy2a (A, horizontal lines), upregulates AP2 (B) and reduces XK70 keratin expression (C). dnWnt11 inhibits FoxD3 (D) but does not have an effect on Sox2 (E). Wnt11R MO1 reduces AP2 expression (F). In A-C, dorsal view is shown, anterior is to the bottom; in D-F, dorso-anterior view is shown. Arrows indicate changes in marker expression. Image published in: Ossipova O and Sokol SY (2011) Copyright © 2011. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Gene Synonyms Species Stage(s) Tissue hes4.S H2, hairy2, hairy2a, hairy2b, hes4-a, hes4-b, hes4a, hes4b, Xhairy2, XHairy2a, Xhairy2b X. laevis Sometime during NF stage 14 to NF stage 15 neural crest tfap2a.L ap2, AP2a, AP2alpha, tfap2a-a, tfap2a-b, tfap2alpha, XAP-2, xap2 X. laevis Throughout NF stage 14 to NF stage 15 anterior neural fold krt70.S krt, krt-a, krt-b, xk70 X. laevis Sometime during NF stage 14 to NF stage 15 epidermis foxd3.L fkh6, foxd3-a, foxd3-b, XFD-6, xfoxd3 X. laevis Sometime during NF stage 14 to NF stage 15 neural crest sox2.L anop3, LOC108718087, mcops3, Sox-2, XLSOX-2, Xsox-2, XSox2 X. laevis Sometime during NF stage 14 to NF stage 15 pre-chordal neural plate chordal neural plate Image source: Published Larger Image Printer Friendly View

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