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Fig. 5. Effects of Dlx3 or GATA2 gain or loss of function on non-neural ectodermal markers. (A-G′′) Neural plate stage embryos after unilateral injection (lower half; marked by light blue β-galactosidase or green mycGFP staining) of various constructs as indicated. Reductions (arrows) and broadening or ectopic expression domains (asterisks) in the neural (green) and non-neural (orange) ectoderm compared with the control side (arrowheads) are indicated. Insets depict additional embryos with ectopic expression of Six1 (A), Eya1 (B) and Dlx5 (D) in central neural plate. Image published in: Pieper M et al. (2012) Copyright © 2012. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Gene Synonyms Species Stage(s) Tissue six1.L XSix1 X. laevis Throughout NF stage 18 anterior placodal area eya1.L eyes absent-1, XEya1 X. laevis Throughout NF stage 18 anterior placodal area foxi2.S foxi2-a, foxi2-b X. laevis Throughout NF stage 18 neural plate anterior placodal area dlx5.L dll3, X-dll3 X. laevis Throughout NF stage 18 neural plate non-neural ectoderm neural plate border cement gland primordium anterior placodal area gata2.L GATA-2, xGATA-2, xgata2 X. laevis Throughout NF stage 20 non-neural ectoderm neural plate border krt12.4.L ck81, cytok, cytokeratin, E-keratin, epi-keratin, epidermal keratin, Epidermis-specific keratin, EpiK, epiker, EpK, epK, K81, xK81, xk81a, xk81a1 X. laevis Throughout NF stage 22 non-neural ectoderm epidermis Image source: Published Experiment + Assay Source Phenotypes and Disease Xla Wt + dlx3 + NF16 (in situ hybridization) fig.5.a Expression Phenotype increased amount six1.L expression in neuroectoderm mislocalised six1.L expression in neuroectoderm Xla Wt + dlx3 + NF16 (in situ hybridization) fig.5.a Expression Phenotype decreased amount six1.L expression in non-neural ectoderm Xla Wt + gata2 + NF16 (in situ hybridization) fig.5.a' Expression Phenotype decreased amount six1.L expression in non-neural ectoderm Xla Wt + dlx3 MO + NF16 (in situ hybridization) fig.5.a^1 Expression Phenotype decreased amount six1.L expression in non-neural ectoderm Xla Wt + gata2 MO + NF16 (in situ hybridization) fig.5.a^3 Expression Phenotype decreased amount six1.L expression in non-neural ectoderm Xla Wt + dlx3 + NF16 (in situ hybridization) fig.5.b Expression Phenotype mislocalised eya1.L expression in neuroectoderm increased amount eya1.L expression in neuroectoderm Xla Wt + dlx3 + NF16 (in situ hybridization) fig.5.b Expression Phenotype decreased amount eya1.L expression in non-neural ectoderm Xla Wt + gata2 + NF16 (in situ hybridization) fig.5.b' Expression Phenotype decreased amount eya1.L expression in non-neural ectoderm Xla Wt + dlx3 MO + NF16 (in situ hybridization) fig.5.b^1 Expression Phenotype decreased amount eya1.L expression in non-neural ectoderm Xla Wt + gata2 MO + NF16 (in situ hybridization) fig.5.b^3 Expression Phenotype decreased amount eya1.L expression in non-neural ectoderm Xla Wt + dlx3 + NF16 (in situ hybridization) fig.5.c Expression Phenotype increased amount foxi1.L expression in neuroectoderm mislocalised foxi1.L expression in neuroectoderm Xla Wt + dlx3 + NF16 (in situ hybridization) fig.5.c Expression Phenotype decreased amount foxi1.L expression in non-neural ectoderm Xla Wt + gata2 + NF16 (in situ hybridization) fig.5.c' Expression Phenotype decreased amount foxi1.L expression in non-neural ectoderm Xla Wt + dlx3 MO + NF16 (in situ hybridization) fig.5.c^1 Expression Phenotype decreased amount foxi1.L expression in non-neural ectoderm Xla Wt + gata2 MO + NF16 (in situ hybridization) fig.5.c^3 Expression Phenotype decreased amount foxi1.L expression in non-neural ectoderm Xla Wt + dlx3 + NF16 (in situ hybridization) fig.5.d Expression Phenotype increased amount dlx5.L expression in neuroectoderm mislocalised dlx5.L expression in neuroectoderm Xla Wt + dlx3 + NF16 (in situ hybridization) fig.5.d Expression Phenotype decreased amount dlx5.L expression in non-neural ectoderm Xla Wt + gata2 + NF16 (in situ hybridization) fig.5.d' Expression Phenotype decreased amount dlx5.L expression in non-neural ectoderm Xla Wt + dlx3 MO + NF16 (in situ hybridization) fig.5.d^1 Expression Phenotype decreased amount dlx5.L expression in non-neural ectoderm Xla Wt + gata2 MO + NF16 (in situ hybridization) fig.5.d^3 Expression Phenotype decreased amount dlx5.L expression in non-neural ectoderm Xla Wt + dlx3 + NF16 (in situ hybridization) fig.5.e Expression Phenotype decreased amount gata2.L expression in non-neural ectoderm Xla Wt + dlx3 MO + NF16 (in situ hybridization) fig.5.e^1 Expression Phenotype decreased amount gata2.L expression in non-neural ectoderm Xla Wt + gata2 + NF16 (in situ hybridization) fig.5.f Expression Phenotype increased amount dlx3.L expression in neuroectoderm mislocalised dlx3.L expression in neuroectoderm Xla Wt + gata2 MO + NF16 (in situ hybridization) fig.5.f^1 Expression Phenotype decreased amount dlx3.L expression in non-neural ectoderm Xla Wt + dlx3 + NF16 (in situ hybridization) fig.5.g Expression Phenotype decreased amount krt70.S expression in non-neural ectoderm Xla Wt + gata2 + NF16 (in situ hybridization) fig.5.g' Expression Phenotype decreased amount krt70.S expression in non-neural ectoderm Xla Wt + dlx3 MO + NF16 (in situ hybridization) fig.5.g^1 Expression Phenotype decreased amount krt70.S expression in non-neural ectoderm Xla Wt + gata2 MO + NF16 (in situ hybridization) fig.5.g^3 Expression Phenotype decreased amount krt70.S expression in non-neural ectoderm Larger Image Printer Friendly View

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