Xenbase Image ID: 76629

Fig. 2. Nanos1-depleted PGCs enter apoptosis. (A) PGCs deficient in Nanos1 are not apoptotic throughout early development (stage 18). WISH Xpat (germ plasm marker, green) and TUNEL staining (red) of WT, Nanos1-Ctrl-MO- and Nanos1-MO-injected embryos. Arrows indicate TUNEL-positive cells in neural ectoderm. (B) TUNEL-positive PGCs are detected during tailbud stage (stage 28) in Nanos1-depleted embryos, but not in control embryos. Arrows indicate TUNEL-positive PGCs. Confocal images were taken from the region indicated in the diagram (red box). Scale bars: 100 μm in A; 150 μm in B. Image published in: Lai F et al. (2012) Copyright © 2012. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Gene Synonyms Species Stage(s) Tissue pgat.L Xpat X. laevis Throughout NF stage 18 germ cell pgat.L Xpat X. laevis Throughout NF stage 28 germ cell Image source: Published Experiment + Assay Source Phenotypes and Disease Xla Wt + nanos1 MO + NF26-29/30 (immunohistochemistry) fig.2.b Anatomical Phenotype increased apoptosis in primordial germ cell Larger Image Printer Friendly View

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