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Fig. 5. Overexpression of brunol1 results in an overproliferation phenotype. Enlarged pancreas phenotype seen in embryos injected with brunol1 mRNA injected into 2 dorsal-vegetal blastomeres at the eight-cell stage. (A,B) ptf1a expression (n=12). Arrow points to the ectopic pancreas. (C,D) No expression of insulin is detected in the ectopic pancreas (n=24). Pancreas is outlined. (E,F) elastase is expressed in the ectopic pancreatic tissue (arrow, n=23). (G,H) frp5 expression is normal (n=10). Arrow points to overgrowth. (I,J) Expression of the liver marker hex is normal, though the liver does appear a little larger (n=14). (K,L) Trace drawing of panels A and B illustrating the overgrowth of pancreatic tissue in the tadpoles injected with brunol1 mRNA. Image published in: Horb LD and Horb ME (2010) Copyright © 2010. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue ptf1a.S ptf1a-a, ptf1a-b, Ptf1a/p48, XPtf1a X. laevis Throughout NF stage 41 pancreas dorsal pancreatic bud ventral pancreatic bud ins.S ins-a, ins-b, ins1, insulin, insulin I, preproinsulin, xins X. laevis Throughout NF stage 41 pancreas dorsal pancreatic bud cela1.2.L elastase X. laevis Throughout NF stage 41 pancreas dorsal pancreatic bud ventral pancreatic bud sfrp5.L frp5, sFRP-5, sfrp5-a, sfrp5-b, XsFRP5 X. laevis Throughout NF stage 40 to NF stage 41 alimentary system stomach duodenum gall bladder hhex.L hex, tHex, XHex X. laevis Throughout NF stage 41 liver primordium Image source: Published Larger Image Printer Friendly View

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