Xenbase Image ID: 76848

Figure 3. Fgf signalling is required for lung and elements of thyroid differentiation in Xenopus. When embryos were treated with SU5402 at either stage 12, 20 or 26, expression of nkx2.1 was lost in the lung (green arrows) but not the thyroid (red arrows) or anterior neural tissue. Although treatment with SU5402 at stage 20 caused clear deformations in the lens ectoderm expression (yellow arrows) of foxe4, there was no clear effect on the thyroid expression of foxe4. Expression of pax2 in the thyroid was lost when SU5402 was applied at stage 12 but expression of pax2 was observed in most embryos at stage 20 and all embryos when treated at stage 26. Note the severe tail defects in embryos treated with SU5402 at stage 12 demonstrating the effectiveness of the block to Fgf signalling. (side - side view, ventral - ventral view). Image published in: Wang JH et al. (2011) Copyright ©2011 Wang et al; licensee BioMed Central Ltd. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Gene Synonyms Species Stage(s) Tissue nkx2-1.L nkx2.1, titf1, ttf1, Xnkx-2.1, xnkx2-1 X. laevis Throughout NF stage 37 and 38 lung thyroid endoderm lung primordium thyroid primordium brain forebrain telencephalon olfactory bulb otic vesicle head region foregut foxe3.L foxe1, FoxE4, lens1, Xlens1 X. laevis Throughout NF stage 37 and 38 thyroid endoderm lens ectoderm pax2.L LOC108697493, pax-2, pax2-a, pax2-b, XPax-2, XPax2 X. laevis Throughout NF stage 37 and 38 thyroid endoderm neuroectoderm brain forebrain telencephalon olfactory bulb pharyngeal arch anterior branchial crest posterior branchial crest hyoid crest hindbrain neural tube posterior neural tube pronephric kidney pronephric nephron pronephric duct early distal tubule Image source: Published Larger Image Printer Friendly View

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