Xenbase Image ID: 76851

Figure 5. Exogenous retinoic acid signalling results in the loss of early thryroid gene expression. When embryos are treated with retinoic acid (RA) at stage 24/26, expression of sftpb was detected in the thyroid (red arrows) and in the lung (green arrows) but it is only expressed in the lung in control (DMSO) embryos. Pax2 and foxe4 are normally expressed in the thyroid although both have distinct expression domains in other tissues. Embryos treated with RA still expressed both pax2 and foxe4 but the expression in the thyroid was eliminated. Expression of foxe1 could be observed in all embryos, particularly in the pharynx, but expression in the thyroid was undetectable. Treatment with the retinoic acid antagonist at stage 26 did not eliminate the expression of any tested markers in either the thyroid or lung. Image published in: Wang JH et al. (2011) Copyright ©2011 Wang et al; licensee BioMed Central Ltd. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Gene Synonyms Species Stage(s) Tissue sftpb.L SP-B, xSP-B X. laevis Throughout NF stage 37 and 38 lung endoderm head region lung primordium nkx2-1.L nkx2.1, titf1, ttf1, Xnkx-2.1, xnkx2-1 X. laevis Throughout NF stage 37 and 38 lung thyroid endoderm neuroectoderm forebrain telencephalon olfactory bulb pax2.L LOC108697493, pax-2, pax2-a, pax2-b, XPax-2, XPax2 X. laevis Throughout NF stage 37 and 38 thyroid endoderm otic vesicle pronephric kidney pronephric nephron pronephric duct brain hindbrain neural tube posterior neural tube lens ectoderm foxe3.L foxe1, FoxE4, lens1, Xlens1 X. laevis Throughout NF stage 37 and 38 thyroid endoderm lens ectoderm foxe1.L ttf2 X. laevis Throughout NF stage 37 and 38 pharyngeal arch pharynx Image source: Published Larger Image Printer Friendly View

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