Xenbase Image ID: 76974

Fig. 1. Fgf signalling is necessary for proper LPM pattern. Foxf1, hand1, sall3 and Xbra were assayed for a response in expression domain when Fgf signalling was inhibited with SU5402. The anterior domain, marked by foxf1 expression (A–D), was expanded toward the ventral side of the embryo (arrowheads in A and B), and was upregulated at the posterior end of the LPM just ventral to the blastopore (arrowheads in C and D). The posterior border of hand1 (E–H) is displaced further posterior, particularly at the dorsal edges of the domain (arrowheads in E–H). The LPM domain of sall3 (I–L) is displaced posterior with a loss of Fgf signalling (white arrowheads in K and L) while the posterior neural tube domain is undetectable (black arrowheads in K and L). Expression of Xbra in the tailbud domain is completely lost in the absence of Fgf signalling (arrowheads in M and N). llv: left lateral view, embryos oriented with the anterior pole toward the left of the image, dorsal at top. pos: posterior view, embryos oriented with dorsal at top of image. The total number of embryos examined for each panel is indicated in the lower left hand corner. Image published in: Deimling SJ and Drysdale TA (2011) Copyright © 2011. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue foxf1.L acdmpv, fkhl5, foxf1-a, foxf1-b, freac1, xfd-13 X. laevis Throughout NF stage 20 lateral plate mesoderm hand1.L eHand, hand-1 X. laevis Throughout NF stage 20 lateral plate mesoderm involuted ventral mesoderm sall3.L X-sal, Xsal-1, Xsal-3 X. laevis Throughout NF stage 20 lateral plate mesoderm posterior neural tube tbxt.S bra, brachyury, ntl, t, t-a, t-b, X-bra, Xbra, Xbrachyury X. laevis Throughout NF stage 20 posterior neural tube circumblastoporal collar Image source: Published Larger Image Printer Friendly View

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