Xenbase Image ID: 76982

Fig. 9. Loss of retinoic acid signalling partially rescues effects of loss of Fgf signalling on the domains of isl1 and Xbra. Decreasing RA signalling in SU5402 treated embryos had little effect on the nkx2.5 domain (D) as it was still present in a highly restricted domain similar to the SU5402 treatment (C). However, a loss of Fgf signalling leads to a loss of isl1 (H) and Xbra (T), while neither domain is changed when RA signalling is lost (F and R). However, when Fgf signalling is decreased in conjunction with reduced RA signalling both isl1 and Xbra expression is detectable in their normal domains (H and T). However, the restriction of the hand1 expression domain under reduced RA condition (J and N) seems to be dominant to the extended domain seen in the SU5402 treated embryos (K and O) as losing both RA and Fgf signalling (L) leads to a restricted domain similar to the RA antagonist alone. Image published in: Deimling SJ and Drysdale TA (2011) Copyright © 2011. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue tbxt.S bra, brachyury, ntl, t, t-a, t-b, X-bra, Xbra, Xbrachyury X. laevis Throughout NF stage 20 circumblastoporal collar mesoderm hand1.L eHand, hand-1 X. laevis Throughout NF stage 20 lateral plate mesoderm involuted ventral mesoderm nkx2-5.L AR2, csx, Nkx-2.5, nkx-2.5, nkx2-5-a, nkx2-5-b, nkx2.5, tinman, XNkx-2.5, XNkx2-5 X. laevis Throughout NF stage 20 cardiac mesoderm isl1.S islet-1, islet1, Xisl-1, Xislet-1 X. laevis Throughout NF stage 20 cardiac progenitor cell neural crest anterior neural ridge cardiac mesoderm Image source: Published Larger Image Printer Friendly View

Return to previous page