Xenbase Image ID: 76987

Supplementary Fig. 1. Inhibiting Vegf signalling with KRN633, a vegfr specific inhibitor does not recapitulate the SU5402 phenotype. Treating embryos with either 10 μM, or 25 μM KRN633 leads to a loss of angiogenesis when embryos are assayed for either etv2 (G–L) or aplnr (M–R) as demonstrated by a loss of vascular budding in the ventral trunk, and a loss of intersomitic vessels (white arrow heads). However, no concentration tested was able to block expression of tnni3 (A–F), or cause significant truncations of the tail. Image published in: Deimling SJ and Drysdale TA (2011) Copyright © 2011. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue tnni3.L c-troponin, cardiac tropin T, cardiac troponin I, cTnI, ctnIc, cTNT, TIc, TnIc, tnnic, troponin-ic, XcTnI, XTnIc X. laevis Throughout NF stage 28 to NF stage 29 and 30   etv2.L er71, ets1, ets2-like, Etsrp, etsrp71 X. laevis Throughout NF stage 28 to NF stage 29 and 30 periotic region anterior lymph sac cardinal vein intersomitic vessel vascular plexus aortic arch aplnr.L agtrl1, angio1, apj, apjr, aplnr-a, aplnr-b, hg11, msr, X-msr, Xangio1, Xmsr X. laevis Throughout NF stage 28 to NF stage 29 and 30 periotic region head region tail tip aortic arch cardinal vein intersomitic vessel vascular plexus Image source: Published Larger Image Printer Friendly View

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