Xenbase Image ID: 77632

Fig. 8. Correlation between C-E morphogenesis and L–R patterning. (A) Percentage of control morphant (CTRL MO) and Zic3 morphant embryos with defective C-E phenotypes. (B) Percentage of control and Zic3 morphants with L–R patterning abnormalities. (C) Comparison of control and Zic3 morphants with defective C-E (score based on scale represented in Fig. 1D) and abnormal L–R patterning (based on pitx2 expression in the lateral plate mesoderm). C-E defects are categorized as normal to mild (C-E score of 1–3) and severe (C-E score of 4–5). **p < 0.01 by Fisher's exact test; statistical significance was determined through comparison of each experimental group with the CTRL MO (normal–mild CE) group. Image published in: Cast AE et al. (2012) Copyright © 2012. Image reproduced with permission of the Publisher, Elsevier B. V. Experiment + Assay Source Phenotypes and Disease Xla Wt + zic3 MO + NF31 (morphology) fig.8.a Anatomical Phenotype abnormal convergent extension Xla Wt + zic3 MO + NF46 (morphology) fig.8.b Anatomical Phenotype abnormal left/right axis specification Larger Image Printer Friendly View

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