Xenbase Image ID: 77794

Fig. 7. Expression of a dominant negative Su(H) does not affect Hox expression. Non-injected controls (Nic; A,C,E,G) and embryos injected in the left-hand side with dominant negative Su(H) [Su(H)DBM; B,D,F,H] were analysed at neurula stage for the expression of ESR4 (A,B: 85%, n=35) and X-Delta-2 (C,D: 86%, n=37), and at gastrula stage for the expression of Hoxd1 (E,F: 100%, n=21) and Hoxc6 (G,H: 100%, n=23) by whole-mount in situ hybridisation. Embryos at neurula stage are shown from the dorsal side, anterior up, and gastrula embryos from the vegetal side, dorsal up. Su(H)DBM works as a dominant negative affecting the downstream genes of the Notch pathway, ESR4 (B) and inhibiting the X-Delta-2 downregulation in the somitomere region (D) but does not show any effect on Hox expression (F,H). The arrowhead indicates the injected side of the embryo. Image published in: Peres JN et al. (2006) Copyright © 2006. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue hes7.2.L enhancer-of-split-related 4, ESR 4, ESR-4, esr4 X. laevis Throughout NF stage 12 paraxial mesoderm presomitic mesoderm dlc.L delta-2, delta2, dll3, x-delta-2, X-Delta2 X. laevis Throughout NF stage 14 posterior presomitic mesoderm hoxd1.S MGC131028, Xhox.lab, xhox.lab1, xhoxd1, xlab, Xlab-1 X. laevis Throughout NF stage 11 mesoderm dorso-lateral marginal zone involuted dorsal mesoderm hoxc6.S ACI, xeb1, XlHbox1 X. laevis Throughout NF stage 12.5 circumblastoporal collar marginal zone ventral marginal zone ventro-lateral marginal zone dorso-lateral marginal zone dorsal marginal zone Image source: Published Larger Image Printer Friendly View

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