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XB-IMG-77879

Xenbase Image ID: 77879


Fig. 2. Osr1/Osr2 are required for respiratory specification and tracheal-esophageal separation. (A-L′) Embryos were co-injected with control MM-MOs or Osr1/Osr2-MOs and GR-mOsr1 RNA (250 pg) in both dorsal-vegetal blastomeres at the eight-cell stage (bilateral injection) and then cultured ±dexamethasone from stage 20 onwards. (A-C,G-I) Analysis by in situ hybridization of nkx2.1 at stage 34/35 (A-C) and sftpc at stage 42 (G-I). (D-F′,J-L′) Confocal immunofluorescence of Nkx2.1 (green) and Sox2 (red) at stage 35/36 (D-F) and stage 42 (J-L). es, esophagus; tr, trachea; lb, lung buds; st, stomach, Scale bars: 100 μm. [Curators Note: all embryos X. laevis]

Image published in: Rankin SA et al. (2012)

Copyright © 2012. Image reproduced on Xenbase with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.

GeneCloneSynonymsSpeciesStage(s)Tissue
nkx2-1.L ttf1, nkx2.1, titf1, Xnkx-2.1, xnkx2-1X.laevisSometime during NF stage 33 and 34 to NF stage 35 and 36lung
endoderm
foregut
thyroid primordium
brain
forebrain
olfactory bulb
sftpc.S SP-C, xSP-C, SPC, surfcX.laevisThroughout NF stage 42lung
endoderm
respiratory system
nkx2-1.L ttf1, nkx2.1, titf1, Xnkx-2.1, xnkx2-1X.laevisThroughout NF stage 42lung
endoderm
trachea
foregut
lung primordium
nkx2-1.L ttf1, nkx2.1, titf1, Xnkx-2.1, xnkx2-1X.laevisSometime during NF stage 33 and 34 to NF stage 35 and 36lung
endoderm
respiratory system
lung primordium
sox2.S XLSOX-2, Sox-2, XSox2, Xsox-2, anop3, mcops3X.laevisThroughout NF stage 33 and 34 to NF stage 42endoderm
esophagus
stomach

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