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XB-IMG-77881

Xenbase Image ID: 77881


Fig. 4. FGF, Wnt/β-catenin and RA signaling regulate Xenopus lung development in a pathway with Osr1/Osr2. (A-D) Embryos were treated from stages 25-35 with DMSO vehicle (A), 100 μM PD173074 (B), 50 μM XAV939 (C) or 10 μM BMS493 (D), and assayed at stage 35 with the indicated probes. (E). Embryos were treated between stages 28 and 35 with vehicle (DMSO), 10 μM BIO, 80 μM SU5402, a combination of 80 μM SU5402 + 10 μM BIO, 10 μg/ml cycloheximide (CHX) or CHX +10 μM BIO, and analyzed for nkx2.1 at stage 35 and sftpc at stage 40. Black arrows indicate normal expression, red arrows indicate absent expression, yellow arrows indicate reduced expression and green arrows indicate expanded or rescued expression.

Image published in: Rankin SA et al. (2012)

Copyright © 2012. Image reproduced on Xenbase with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.

GeneCloneSynonymsSpeciesStage(s)Tissue
nkx2-1.L ttf1, nkx2.1, titf1, Xnkx-2.1, xnkx2-1X.laevisSometime during NF stage 28 to NF stage 32foregut
endoderm
lung primordium
brain
forebrain
midbrain
hindbrain
head
pharyngeal arch
eye
thyroid primordium
sox2.S XLSOX-2, Sox-2, XSox2, Xsox-2, anop3, mcops3X.laevisSometime during NF stage 33 and 34 to NF stage 35 and 36brain
pharyngeal arch
eye
head
endoderm
foregut
otic vesicle
spinal cord
wnt2b.L Xwnt-2b, xwnt2b, wnt-2b, wnt2b-a, wnt2b-bX.laevisSometime during NF stage 33 and 34 to NF stage 35 and 36lateral plate mesoderm
pharyngeal arch
pineal gland
lens placode
otic vesicle
aldh1a2.L raldh2, XRaldh2, raldh-2X.laevisSometime during NF stage 33 and 34 to NF stage 35 and 36brain
lens
otic vesicle
periocular region
pronephric kidney
pronephric duct
adenohypophyseal placode
midbrain
hindbrain
osr1.S odd1X.laevisSometime during NF stage 33 and 34 to NF stage 35 and 36endoderm
foregut
lateral plate mesoderm
brain
pronephric kidney
pronephric duct
adenohypophyseal placode
eye
osr2.S xosr2, osr2-b, osr2-aX.laevisSometime during NF stage 33 and 34 to NF stage 35 and 36endoderm
foregut
lateral plate mesoderm
pronephric kidney
pronephric duct
head region
nkx2-1.L ttf1, nkx2.1, titf1, Xnkx-2.1, xnkx2-1X.laevisThroughout NF stage 35 and 36endoderm
lung primordium
brain
thyroid primordium
eye

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