Xenbase Image ID: 78250

Figure 3. Effects of c-SMRT mRNA and morpholino oligonucleotide microinjection on Xenopus development. (a) Treatment with 10−6 RA causes anterior truncations; (b) c-SMRT overexpression causes anterior truncation similar to those elicited by RA treatment; (c) embryos microinjected with 10 ng of a control morpholino antisense oligonucleotide; (d) embryos microinjected with 10 ng of a morpholino antisense oligonucleotide directed against xRARα1; (e) embryos microinjected with 10 ng of a morpholino antisense oligonucleotide directed against xRARα2; (f) embryo microinjected with 10 ng of a morpholino antisense oligonucleotide directed against both xRARα1 and xRARα2; (g) 10 ng of the xRARα2 morpholino was rescued by coinjection with 500 pg of xRARα2 mRNA; (h) 10 ng of the xRARα2 morpholino was rescued by coinjection with 500 pg of dominant-negative xRARα mRNA; (i) 10 ng of the xRARα2 morpholino was not rescued by coinjection with 500 pg of constitutively active VP16–xRARα mRNA. Image published in: Koide T et al. (2001) Copyright © 2001. Image reproduced on with permission of the Publisher, Cold Spring Harbor Laboratory Press. This is an Open Access article. Larger Image Printer Friendly View

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