XB-IMG-78278
Xenbase Image ID: 78278
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FIG. 2. Schematic diagram of notochord signaling to dorsal pancreatic
endoderm. Red indicates SHH expression, blue indicates
pdx1 expression, and yellow indicates pancreatic markers. (A)
Signals from the notochord cause repression of SHH expression
(red) in the pancreatic endoderm and expression of pancreatic
genes, such as pdx-1 (blue). (B) The pancreatic buds develop on
dorsal and ventral portions of the gut tube, surrounded by mesenchyme
(indicated by squiggly lines). Both pancreatic buds express a
range of pancreatic markers (yellow). (C) When the notochord is
removed, the dorsal bud evaginates, but does not undergo further
branching and morphogenesis. In addition, SHH expression is
initiated in the dorsal pancreatic epithelium and pancreatic markers
are repressed. The ventral bud develops unhindered. Image published in: Cleaver O and Krieg PA (2001) Copyright © 2001. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View |