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Fig. 7. Overexpression of FOG-2 and xFOG inhibits erythropoiesis. The interaction with CtBP appears to be, at least in part, responsible for this inhibition. (A,C,E) Anesthetized tadpoles; (B,D,F,G-J) Tadpoles stained with o-dianisidine. Uninjected (A) tadpoles have beating hearts that pump red blood, whereas Fog-2-injected (C) tadpoles have a beating heart (indicated by black arrow) that pumps very pale blood cells. Fog∆CtBP-injected (E) tadpoles have a beating heart that pumps very red blood. Globin-expressing red cells, stained with o-dianisidine, are noticeable along the tail vein and in the heart in uninjected tadpoles (B,G, indicated by arrows), in tadpoles injected with a negative control (3′-5′) xFog RNA (H, white arrows point to staining in major veins), but not in Fog-2 or xFog- injected tadpoles (D,I,J). Tadpoles injected with Fog∆CtBP (F) display normal o- dianisidine staining. Image published in: Deconinck AE et al. (2000) Copyright © 2000. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

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