Xenbase Image ID: 78283

Fig. 8. In the absence of CtBP binding, FOG-2 stimulates stem cell proliferation, but maturation and differentiation is not occurring as normal. (A,B,D,E,G,H) Tadpole blood, stained with o-dianisidine and cytospun (original magnification A,D,G, 00; others, 00). (C,F,I) May Grwald Giemsa (MGG) staining of tadpole blood smears. Tadpoles injected with Fog-2 have fewer red blood cells (D), which are paler when stained with o-dianisidine, and rounder (E), compared to uninjected (A,B). Tadpoles injected with Fog∆CtBP have a striking increase in number of red blood cells (G), but not all these blood cells are normal in appearance (H, arrowhead) when compared to stage-matched wild-type sibling controls. Red blood cells collected from wild-type tadpoles have compacted nuclei (C), whereas blood cells from tadpoles injected with Fog-2 look developmentally delayed (F). A mixture of normal and developmentally delayed blood cells (arrow and arrowhead, respectively) are found in tadpoles injected with Fog∆CtBP (I). Image published in: Deconinck AE et al. (2000) Copyright © 2000. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

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