Xenbase Image ID: 78696

Fig. 3. In vivo inactivation of miR-129, miR-155, miR-214, and miR-222 supports the bipolar cell fate. (A–G) Sections of retinas, lipofected with control (A) or antisense to miRNAs (a-miRNAs, B–G) oligonucleotides, show morphology of lipofected cells (GFP positive, white detection) in the differentiated cell layers: outer nuclear layer (ONL), inner nuclear layer (INL), and ganglion cell layer (GCL). Bipolar cells are located in the INL. a-miR-mix is an equimolar mix of antago-miRNAs to mir-129, miR-155, miR-214, and miR-222. (H) Heat map shows the percentage ratio (red to blue) of neuronal (ganglion, horizontal, amacrine, photoreceptor, and bipolar) and glial (Müller) cells in retinas lipofected with antisense oligonucleotides to miRNAs (a-miR) as reported in Table S3. Image published in: Decembrini S et al. (2009) Copyright © 2009. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

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