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Fig. 8. Overexpression of Evi1-VP16-hGR disrupts distal and expands early proximal markers. (A, I, O) Lateral views and (G, H, M, N and Q, R) sections through the pronephros of tailbud or early tadpole stage embryos coinjected with Evi1-VP16-hGR mRNA and β-galactosidase mRNA and stained with the indicated markers. Control and injected sides marked with Red-gal are shown. Note the inhibition of the expression of the expression of the XClC-K (A, B) and Gremlin (C, D) distal tubule and duct markers (arrowheads), the expansion of the xWT1 (E) and nephrin (I, J) glomus and X-Delta-1 (K) and EphA4 (O, P) early proximal markers (arrows). (Q) Example of injected embryos with reduced proximal tubules. (R) Example of an embryo with a pronephros containing additional tubule branches and ectopic xPDZK1 staining (arrow). Abbreviations: pn, pronephros; spm, splanchnic layer of the mesoderm; pt, proximal tubules. Image published in: Van Campenhout C et al. (2006) Copyright © 2006. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue clcnkb.L ClC-k, clc-kb, clckb, clcnka, clk-k2, xClC-k X. laevis Throughout NF stage 28 pronephric tubule early distal tubule pronephric mesenchyme wt1.S wt-1, wt1-a, wt1-b, Xwt-1, xwt1 X. laevis Throughout NF stage 26 splanchnic layer of lateral plate mesoderm nphs1.S nephrin X. laevis Throughout NF stage 28 pronephric mesenchyme dll1.L delta-1, Delta-1, delta1, x-delta, X-delta-1, Xdelta-1, Xdelta1, XDelta1 X. laevis Throughout NF stage 24 eye pronephric mesenchyme brain epha4.S eph-a4, epha4-a, epha4-b, hek8, Pag, Pagliaccio, rtk1, sek, sek-1, tyr01, XEpha4 X. laevis Throughout NF stage 26 pronephric mesenchyme neural crest pdzk1.L xpdzk1 X. laevis Throughout NF stage 28 early proximal tubule head region spinal cord Image source: Published Larger Image Printer Friendly View

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