Xenbase Image ID: 79081

Fig. 3. Rfx6 is required for pancreas differentiation. Whole mount in situ hybridizations of NF42 whole guts from morphant (MO1) and mis-match (control) tadpoles. (A–D) Expression of pancreatic transcription factors pdx1 (n = 18) and ptf1a (n = 18) is almost completely abolished in morphant tissue. (E, F) Expression of acinar marker elastase is reduced (n = 16). (G, H) Schematic illustrating organs in the whole gut. Pink, liver; red, gall bladder; blue, pancreas; yellow, stomach, duodenum and intestine. (I, J) β cell marker insulin is reduced (72/75 reduced). (K–N) Glucagon and somatostatin, both markers of endocrine cells in the pancreas and stomach are reduced (glucagon n = 18, somatostatin 15/16 reduced). (O, P) NeuroD, developmental endocrine cell marker, is reduced (n = 17). Image published in: Pearl EJ et al. (2011) Copyright © 2011. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue pdx1 ipf1, pdx-1, STF-1, XlHbox-8, XlHbox8 X. tropicalis Throughout NF stage 42 stomach ptf1a ptf1a-a, ptf1a-b, Ptf1a/p48, XPtf1a X. tropicalis Throughout NF stage 42 pancreas cela1.6 Elas, Elastase, LOC100135144 X. tropicalis Throughout NF stage 42 pancreas ins ins-a, ins-b, ins1, insulin, insulin I, preproinsulin, xins X. tropicalis Throughout NF stage 42 pancreas sst.1 smst, som, somatostatin X. tropicalis Throughout NF stage 42 stomach neurod1 neurod, neuroD, neurod1-a, neurod1-b, XNeuroD X. tropicalis Throughout NF stage 42 stomach pancreas Image source: Published Larger Image Printer Friendly View

Return to previous page