Xenbase Image ID: 79345

Fig. 3. (A) Profiles of brain cell proliferation during spontaneous metamorphosis and following T3 treatment, measured by the number of BrdU-positive cells. Tadpoles were treated as described for Experiment 3 (see Fig. 1). During spontaneous metamorphosis (Control) cell proliferation was low at premetamorphic (Premet) stages, peaked during prometamorphosis (Promet; NF stage 56–57) and declined at metamorphic climax (Climax; NF stage 62–63). T3 treatment significantly increased cell proliferation at premetamorphic and early prometamorphic stages but failed to alter cell proliferation at later stages. (B) Developmental changes in BrdU labeling in the tadpole optic tectum. There were numerous BrdU-ir cells at prometamorphosis (NF stage 56; b); whereas, there were few BrdU-ir cells in premetamorphic (NF stage 52; a) or late prometamorphic (NF stage 62; c) brains. tect, optic tectum; V, ventricle. Scale bar = 50 μm. Image published in: Denver RJ et al. (2009) Copyright © 2009. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View

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