Xenbase Image ID: 79409

Fig. 4. Misexpression of XRALDH2 mimics the effects of RA in combination with all-trans-retinal. (a) Control embryos at stage 41; (b), embryos which are either mostly unaffected or with partial eye defect or slightly cyclopic (from left to right sequentially) upon 2 μM ATR treatment; (c), embryos without any morphological alterations after 2 ng XRALDH2 overexpression; (d), in the combination of 2 ng XRALDH2 injection and 2 μM ATR treatment, most embryos became microcephalic, and only a few showed a cyclopic eye or traces of eye pigment (white arrows). Image published in: Chen Y et al. (2001) Copyright © 2001. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View

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