Xenbase Image ID: 79499

Fig. 2. δNXMyD88 blocks axis rescue in UV-ventralized Xenopus embryos through the Drosophila Toll receptor and its ligand Spätzle, but not through the Drosophila Rel protein Dorsal. Embryos were scored on the dorsoanterior index scale (DAI; Kao and Elinson, 1988), on which 5 represents wildtype, and 0, fully ventralized embryos (for statistical analysis see Table 1). (A) Uninjected wild-type embryos; UV-ventralized siblings (B) were injected into two opposing blastomeres at 4-cell stage to generate two dorsalizing centers with: (C) Spätzle mRNA (500 pg); (D) Spätzle and δNXMyD88 mRNA (500 pg/100 pg). (E) Toll mRNA (500 pg); (F) Toll and δNXMyD88 mRNA (500 pg/100 pg). (G) Dorsal mRNA (500 pg); (H) Dorsal and δNXMyD88 mRNA (500 pg/100 pg). (I) Comparison of vertebrate and Drosophila Toll-like signaling pathways and their epistatic hierarchies. Image published in: Prothmann C et al. (2000) Copyright © 2000. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View

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