XB-IMG-79768
Xenbase Image ID: 79768
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Fig. 1. The roles of dishevelled in Drosophila and Xenopus development. (A) dsh mutant phenotype during embryogenesis reveals defects in the establishment of segment borders (segment polarity class) and is very similar to wg mutants. A wild-type embryo is shown for comparison. The left panel shows the genetic pathway for wg signaling in this process. (B) The planar polarity phenotypes of the dsh1 allele. Left panels show the ommatidial arrangement in a dorsal area of the eye (wild type on top and dsh1 mutant below), with schematic presentation on the side (black arrow: correct alignment, red arrow: misrotated ommatidium, green arrow: wrong or no chiral form; arrows point towards the dorso-ventral midline of symmetry, the equator). Middle panels show the planar polarity wing phenotype; and right panel shows the genetic pathway required for the interpretation of the planar polarity signal. (C) The role of Dsh in Xenopus axis induction. Overexpression assays of Xenopus components of the Wnt signaling pathway causes axis bifurcation; compare WT with the injected Xdsh (OEXdsh) embryos. The Wnt pathway implicated in axis generation in Xenopus is similar to Wg signaling in Drosophila. Image published in: Boutros M and Mlodzik M (1999) Copyright © 1999. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View |