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Fig. 4. Specific regulation of downstream genes by BMP-4 and Xwnt-8. Embryos were injected with Xwnt-8, BMP-4, dominant negative Xwnt-8 and dominant negative BMP receptor RNAs singly or in combination to achieve BMP-4 overexpression when Xwnt-8 signaling was blocked or Xwnt-8 overexpression when BMP signaling was blocked. Under these conditions the effect on myf-5, Xvent-1 and sizzled expression was determined by RT-PCR. The histone H4 gene served as a loading control.

Image published in: Marom K et al. (1999)

Copyright © 1999. Image reproduced with permission of the Publisher, Elsevier B. V.

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