Xenbase Image ID: 79845

Fig. 7. BMP-4 functions in the refinement of the Xwnt-8 expression pattern during gastrulation. Embryos were injected with BMP-4 mRNA or RNA encoding the dominant negative BMP receptor. (A) Control embryo injected with LacZ RNA exhibiting the normal Xwnt-8 expression pattern at stage 11. (B) Stage 12.5 embryo exhibiting the late gastrula pattern of Xwnt-8 expression. (C) Ventral overexpression of BMP-4 at stage 11 reduces the Xwnt-8 expression along the ventral marginal zone. This modifie0d pattern resembles the late gastrula Xwnt-8 pattern. (D) Blocking BMP-4 signaling with the dominant negative BMP receptor at stage 12.5 allows Xwnt-8 to expand ventrally to resemble the stage 11 pattern. The red and green lines mark the regions along the marginal zone where the Xwnt-8 expression pattern is modified. Image published in: Marom K et al. (1999) Copyright © 1999. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue wnt8a.L wnt-8, wnt8, Xwnt-8, Xwnt8 X. laevis Throughout NF stage 11 ventral marginal zone Image source: Published Larger Image Printer Friendly View

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