XB-IMG-79991
Xenbase Image ID: 79991
|
|
Fig. 4. Inhibition of CREB function leads to phenotypic changes of developing Xenopus embryos. All blastomeres of 4-cell stage embryos were injected
equatorially with CREBA133PR mRNA (750 pg each), and embryos were treated with 1 mM RU486 at the stages indicated and were cultured until stage 40.
Treatment at stage 8 resulted in strong spina bi®da and shortening of the anteroposterior extension, whereas treatment at stage 12 led to stunted embryos with
microcephaly. Injected embryos without RU486 treatment developed normally. Scale bar: 500 mm. Image published in: Lutz B et al. (1999) Copyright © 1999. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View |