Xenbase Image ID: 80515

Fig. 4. Xenopus orthologue of the hairy related gene (XHey-1) is responsive to Notch signaling in the developing brain and pronephros. Embryos were injected with either GR-Su(H)VP16, GR-NotchICD, or GR-Su(H)D B M and induced with dexamethasone either early (between stages 11 and 13) or late (between stages 15 and 19). Injected embryos were cultured, fixed between stages 24 and 30, and processed for in situ hybridization. B: Early activation of Notch signaling decreased both the expression of Lim-1 throughout the entire pronephric field (c,d) as well as the expression of Hey-1 (a,b). Activation of Notch signaling later, after the establishment of the initial Lim-1 pronephric field, decreases expression of only the duct domain of Lim-1 (g,h) while expanding the anterior expression of XHey-1 (c,d, and i,j). Image published in: Rones MS et al. (2002) Copyright © 2002. Image reproduced with permission of the Publisher, John Wiley & Sons. Larger Image Printer Friendly View

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