Xenbase Image ID: 80516

Fig. 4. Xenopus orthologue of the hairy related gene (XHey-1) is responsive to Notch signaling in the developing brain and pronephros. Embryos were injected with either GR-Su(H)VP16, GR-NotchICD, or GR-Su(H)D B Mand induced with dexamethasone either early (between stages 11 and 13) or late (between stages 15 and 19). Injected embryos were cultured, fixed between stages 24 and 30, and processed for in situ hybridization. C: Suppression of Notch signaling decreases Hey-1 expres- sion in embryos induced both early and late (a,b,e,f). In comparison, early suppression of Notch signaling has minimal effects on expression of Lim-1 (c,d). Later suppression of Notch signaling increases the expres- sion of duct specific markers, including the duct domain of Lim-1 (g,h). Image published in: Rones MS et al. (2002) Copyright © 2002. Image reproduced with permission of the Publisher, John Wiley & Sons. Larger Image Printer Friendly View

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