Xenbase Image ID: 80519

Fig. 1. JNK is active in the rearranging endoderm during Xenopus gut elongation. (A-C) Endoderm morphogenesis is depicted in representative sections of the midgut during three stages of gut elongation. At stage 35 (A), the endoderm cells (yellow) of the primitive gut tube have not yet aligned along the apicobasal axis of the gut tube. By stage 40 (B), most of the endoderm cells have become apicobasally aligned. Over subsequent stages, the endoderm cells radially intercalate, as indicated by the black arrows, opening the central lumen, forming the digestive epithelium and driving gut tube elongation. At stage 46 (C), a mature endoderm epithelium lines the fully elongated gut tube. (D-I) Immunohistochemical staining reveals E-cadherin (Ecad, green) and nuclei (blue) or phosphorylated Jun (pJun, red), as indicated. JNK activity is indicated by the accumulation of pJun in the endoderm nuclei at all stages. Scale bars: 50 μm. Image published in: Dush MK and Nascone-Yoder NM (2013) Copyright © 2013. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

Return to previous page