Xenbase Image ID: 80652

Fig. 3. Role of organiser and endomesoderm in placodal Six1 induction. All embryos were analysed at early tailbud stages (stage 206). (A) Grafting a stage 11 organiser (dorsal blastopore lip) into stage 13 belly ectoderm induces Six1 expression (arrowhead) in host ectoderm next to anterior edge of graft. (B) After extirpation of axial mesoderm together with the overlying central neural plate at stage 13 bulging endoderm (asterisk) prevents regeneration of mesoderm and closure of the neural tube without resulting in any major deficits of placodal Six1 expression. (C) Grafting stage 13 cranial dorsolateral endomesoderm (green GFP label) into stage 13 belly ectoderm does not induce Six1 but placodal Six1 expression is lost in donors (D). Control side (CS) shown in insert for comparison. Image published in: Ahrens K and Schlosser G (2005) Copyright © 2005. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue six1.L XSix1 X. laevis Throughout NF stage 13 preplacodal ectoderm Image source: Published Larger Image Printer Friendly View

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