XB-IMG-80801
Xenbase Image ID: 80801
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Figure S3. Chordin/Admp and Sizzled/Bambi mark the dorsal and ventral center and are inversely regulated by BMP levels. (A) The dorsal center or Spemann organizer is marked by Admp expression while the ventral center is marked by Bambi expression. (B) Low BMP levels (achieved by injecting recombinant Chordin protein in the blastocoele cavity) expand Admp expression in the Spemann organizer at the expense of Bambi expression in the ventral center. Admp and Bambi are under opposite transcriptional regulation by the BMP pathway. (C) High BMP levels (achieved by injecting recombinant BMP4 protein in the blastocoele cavity) reduce Admp expression in the Spemann organizer while augmenting Bambi expression in the ventral center. When Admp expression goes down, Bambi expression goes up and vice versa. (D) The dorsal center or Spemann organizer is marked by Chordin expression while the ventral center is marked by Sizzled expression. (E) Low BMP levels expand Chordin expression in the Spemann organizer at the expense of Sizzled expression in the ventral center. Chordin expression is activated by low BMP levels while Sizzled expression is repressed. (F). High BMP levels reduce Chordin expression in the Spemann organizer, while increasing Sizzled expression in the ventral center. When Chordin expression decreases, Sizzled expression increases. Image published in: Reversade B and De Robertis EM (2005) Copyright © 2005. Image reproduced with permission of the Publisher, Elsevier B. V.
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