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XB-IMG-80973

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Fig. S3. The Osr1/2-MO phenotype can be rescued by overexpression of mouse Osr1 RNA. Embryos were co-injected with control MM-MOs or Osr1/2-MOs and GR-mOsr1RNA (250 pg) in both dorsal-vegetal blastomeres at the eight-cell stage (bilateral injection) and then cultured with or without dexamethasone from stage 20 onwards. Analysis by in situ hybridization of nkx2.1, wnt2b, sox2 and bmp4 at stage 34/35 and of sftpc in isolated gut tubes at stage 42. Analysis by immunofluorescence of fibronectin (red), activated caspase 3 (green) and nuclei (blue) at stage 42 show and undivided foregut tube and extensive cell death.

Image published in: Rankin SA et al. (2012)

Copyright © 2012. Image reproduced on Xenbase with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.

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