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XB-IMG-80978

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Fig. S8. BMP signaling that function in a time period after respiratory specification is required for trachea formation and lung bud development. (A,B) In situ hybridization of nkx2.1 expression in embryos treated from stages 35-42 with DMSO (vehicle) or 10 µM LDN193189 to inhibit BMP receptor type I signalling. Red arrows show absent trachea and single dismorphic lung bud. Brain, br; trachea, tr; lung bud, lb. (C,D) Immunofluorescence analysis of Nkx2.1 (green) and Sox2 (red) in serial foregut sections (1 is the anterior-most section, 4 is the posterior-most) reveal loss of trachea, expansion of esophagus and lung bud hypoplasia in LDN-treated embryos.

Image published in: Rankin SA et al. (2012)

Copyright © 2012. Image reproduced on Xenbase with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.

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