XB-IMG-80978
Xenbase Image ID: 80978
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Fig. S8. BMP signaling that function in a time period after respiratory specification is required for trachea formation and lung bud development. (A,B) In situ hybridization of nkx2.1 expression in embryos treated from stages 35-42 with DMSO (vehicle) or 10 µM LDN193189 to inhibit BMP receptor type I signalling. Red arrows show absent trachea and single dismorphic lung bud. Brain, br; trachea, tr; lung bud, lb. (C,D) Immunofluorescence analysis of Nkx2.1 (green) and Sox2 (red) in serial foregut sections (1 is the anterior-most section, 4 is the posterior-most) reveal loss of trachea, expansion of esophagus and lung bud hypoplasia in LDN-treated embryos. Image published in: Rankin SA et al. (2012) Copyright © 2012. Image reproduced on Xenbase with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View |
