XB-IMG-81090
Xenbase Image ID: 81090
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Fig. 5. Myocardin acts in combination with other cardiac
transcription factors to activate endogenous MLC2 expression in
animal cap explants. (A) Expression of myocardin alone (lane
labeled myocardin) activates SM22 and MHCα expression, but is not
sufficient to activate expression of the MLC2 gene. Expression of
Nkx2-5, Gata4, or Tbx5 alone, or the combination of these three
factors (lane labeled N+G+T) is not sufficient to activate expression
of MLC2 or SM22 or MHCa. However, when myocardin is
coexpressed with Nkx2-5, Gata4 and Tbx5, MLC2 gene expression is
activated (lane labeled M+N+G+T). M, myocardin; N, Nkx2-5; G,
Gata4; T, Tbx5. (B) Co-expression of combinations of transcription
factors in animal cap explants shows that any combination of
myocardin and Gata4 is sufficient to activate MLC2 expression. Image published in: Small EM et al. (2005) Copyright © 2005. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View |